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for intramyocellular and extramyocellular lipids (IMCL and EMCL), creatine (Cr), components containing trimethylamine (TMA) group, and acetyl-carnitine detection (water non-suppressed spectra with TE = 280 ms, TR = 2 s and number of transients = 64) [45,46,47]

3 In the REIMAGINE 1 trial, the most commonly reported adverse events (AEs) were gastrointestinal (GI)-related, occurring in 33/62 (53%) participants in the CagriSema 2.4 mg/2.4 mg group, 28/63 (44%) participants in the CagriSema 1 mg/1 mg group, and 13/64 (20%) participants in the placebo group

Liver fat and visceral fat checked at 6 months

Sample aliquots were removed at appropriate intervals for 1 hour and sample contents were determined using a RP-UHPLC method for dual detection of SNAC and GLP-1